[HTML][HTML] Mechanisms of perioperative brain damage in children with congenital heart disease

S Zhu, X Sai, J Lin, G Deng, M Zhao, MI Nasser… - Biomedicine & …, 2020 - Elsevier
Congenital heart disease, particularly cyanotic congenital heart disease (CCHD), may lead
to a neurodevelopmental delay through central nervous system injury, more unstable central …

Polydopamine-Cloaked Nanoarchitectonics of Prussian Blue Nanoparticles Promote Functional Recovery in Neonatal and Adult Ischemic Stroke Models

Y Zhao, C Song, H Wang, C Gai, T Li… - Biomaterials …, 2024 - spj.science.org
Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen species and inflammatory response …

Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in …

Y Yang, G Ye, YL Zhang, HW He, BQ Yu… - Neural regeneration …, 2020 - journals.lww.com
Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced
brain injury. Although mesenchymal stem cell therapy has emerged as a novel treatment for …

Photobiomodulation therapy attenuates hypoxic-ischemic injury in a neonatal rat model

LD Tucker, Y Lu, Y Dong, L Yang, Y Li, N Zhao… - Journal of Molecular …, 2018 - Springer
Photobiomodulation (PBM) has been demonstrated as a neuroprotective strategy, but its
effect on perinatal hypoxic-ischemic encephalopathy is still unknown. The current study was …

Neuroprotective effects of mitochondria-targeted plastoquinone in a rat model of neonatal hypoxic–ischemic brain injury

DN Silachev, EY Plotnikov, IB Pevzner, LD Zorova… - Molecules, 2018 - mdpi.com
Neonatal hypoxia–ischemia is one of the main causes of mortality and disability of
newborns. To study the mechanisms of neonatal brain cell damage, we used a model of …

Differential age-dependent mitochondrial dysfunction, oxidative stress, and apoptosis induced by neonatal hypoxia-ischemia in the immature rat brain

FK Odorcyk, RT Ribeiro, AC Roginski… - Molecular …, 2021 - Springer
Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in
newborns. Experimental studies show that the immature rat brain is less susceptible to HI …

Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in …

Y Zhao, C Gai, S Yu, Y Song, B Gu, Q Luo… - Antioxidants & Redox …, 2025 - liebertpub.com
Aims: Hypoxia ischemia (HI) is a leading cause of cerebral palsy and long-term neurological
sequelae in infants. Given that mitochondrial dysfunction in neurons contributes to HI brain …

[HTML][HTML] Long-term changes in metabolic brain network drive memory impairments in rats following neonatal hypoxia-ischemia

PN Azevedo, G Zanirati, GT Venturin, GG Schu… - Neurobiology of learning …, 2020 - Elsevier
Background and purpose Hypoxia and cerebral ischemia (HI) events are capable of
triggering important changes in brain metabolism, including glucose metabolism …

[HTML][HTML] Therapeutic hypothermia is limited in preventing developmental impairments after neonatal hypoxia-ischemia

RR Nunes, IDÁ Tassinari, J Zang… - Developmental …, 2024 - karger.com
The only current treatment for neonatal hypoxia-ischemia (HI) is therapeutic hypothermia
(TH), which still shows some limitations. Specific effects of TH in the several processes …

Neonatal hypoxia-ischemia caused mild motor dysfunction, recovered by acrobatic training, without affecting morphological structures involved in motor control in rats

HD Confortim, BF Deniz, W de Almeida, PM Miguel… - Brain Research, 2019 - Elsevier
The aim of this study was to evaluated motor function and morphological aspects of the
components involved in motor control (sensorimotor cortex, spinal cord, sciatic nerve …