Gene mutation is associated with cancer and the dissemination of circulating biomarkers
through the blood represents a vital transitional step that exemplifies the shift from localized …

Miniaturization has improved significantly in the recent decade, which has enabled the
development of numerous microfluidic systems. Microfluidic technologies have shown great …

Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and
worse patient prognosis, but are rare, difficult to count, and poorly characterized …

Cell sorting is an essential prerequisite for cell research and has great value in life science
and clinical studies. Among the many microfluidic cell sorting technologies, label-free …

Nanostructured materials have gained significant attention in recent years for their potential
in biological applications, such as cell and biomolecular sorting, as well as early detection of …

Cancer has long been a leading cause of death. The primary tumor, however, is not the
main cause of death in more than 90% of cases. It is the complex process of metastasis that …

Tumor cell clusters are regarded as critical factors in cancer pathophysiology, and
increasing evidence of their higher treatment resistance and metastasis compared to single …

In this study, we developed an ultrathin filtering membrane with slit-shaped pores which can
achieve circulating tumor cell (CTC) separation from whole blood with high performance …

Biomechanical attributes have emerged as novel markers, providing a reliable means to
characterize cellular and subcellular fractions. Numerous studies have identified …

Active deformation behavior reflects cell structural dynamics adapting to varying
environmental constraints during malignancy progression. In most cases, cell mechanics is …