Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

Neurodegeneration is characterized by progressive loss of neurons. Genetic and
environmental factors both contribute to demise of neurons, leading to diverse devastating …

Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for
genetic analysis but is limited by the lack of cell-type-specific gene expression data. Here …

Wolbachia are maternally inherited bacterial endosymbionts that occupy many but not all
tissues of adult insects. During the initial mitotic divisions in Drosophila embryogenesis …

Asymmetrical localization of transcripts coupled with localized translation constitutes an
important mechanism widely deployed to regulate gene activity in a spatial manner. The …

Asymmetric localization of cell fate determinants is a crucial step in neuroblast asymmetric
divisions. Whereas several protein kinases have been shown to mediate this process, no …

Drosophila melanogaster neural stem cells (neuroblasts [NBs]) divide asymmetrically by
differentially segregating protein determinants into their daughter cells. Although the …

The Drosophila central nervous system develops from polarised asymmetric divisions of
precursor cells, called neuroblasts. Decades of research on neuroblasts have resulted in a …

Asymmetric cell divisions generate cell fate diversity during both invertebrate and vertebrate
development. Drosophila neural progenitors or neuroblasts (NBs) each divide …

Due to its intermediate complexity and its sophisticated genetic tools, the larval brain of
Drosophila is a useful experimental system to study the mechanisms that control the …