A wide range of life-threatening conditions with complicated pathogenesis involves
neurovascular disorders encompassing Neurovascular unit (NVU) damage. The …

The extracellular matrix (ECM) is central to the physiology of animal tissues, through its
multifaceted roles in tissue structure, mechanical properties, and cell interactions, and by its …

Abstract Changes in protein glycosylation are a hallmark of transformed cells and modulate
numerous phenomena associated with cancer progression, such as the acquisition of …

We present a detailed mass spectrometric analysis of three 2+ 1 T-cell bispecific monoclonal
antibodies (TCB mAbs), where an unexpected+ 15.9950 Da mass shift in tryptic peptides …

Hydroxylysine glycosylations are post-translational modifications (PTMs) essential for the
maturation and homeostasis of fibrillar and non-fibrillar collagen molecules. The …

Heart failure (HF), as the terminal manifestation of multiple cardiovascular diseases, causes
a huge socioeconomic burden worldwide. Despite the advances in drugs and medical …

Collagens are the most abundant proteins in the body and among the most biosynthetically
complex. A molecular ensemble of over 20 endoplasmic reticulum resident proteins …

Collagens are fundamental constituents of the extracellular matrix and are the most
abundant proteins in mammals. Collagens belong to the family of fibrous or fiber-forming …

Heritable thoracic aortic disease and familial thoracic aortic aneurysm/dissection are
important causes of human morbidity/mortality, most without identifiable genetic cause. In a …

Glycosylation is increasingly recognized as a potential therapeutic target in Alzheimer's
disease. In recent years, evidence of Alzheimer's disease-specific glycoproteins has been …