The granzymes are cell death–inducing enzymes, stored in the cytotoxic granules of
cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis …

Cytotoxic lymphocytes are critical in our immune defence against cancer and infection.
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …

The increase of cell surface sialic acid is a characteristic shared by many tumor types. A
correlation between hypersialylation and immunoprotection has been observed, but few …

Serine proteases form a large family of protein-cleaving enzymes that play an essential role
in processes like blood coagulation, apoptosis and inflammation. Immune cells express a …

B cells currently are not viewed as being capable of producing granzyme B or being
cytotoxic. We found that B-chronic lymphocytic leukemia (B-CLL) cells treated with …

Although proteolysis mediated by granzymes has an important role in the immune response
to infection or tumours, unrestrained granzyme activity may damage normal cells. In this …

Since the prognosis for children with high-risk osteosarcoma (OS) remains suboptimal
despite intensive multi-modality therapies, there is a clear and urgent need for the …

Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their
mechanism of action is not well understood. Decoding the mechanisms used by individual T …

Although the study of natural killer (NK) cell alloreactivity has been dominated by studies of
killer cell immunoglobulin-like receptors (KIRs), we hypothesized that NKG2A and LIR-1 …

Estrogens promote cell proliferation and metastases in several human cancers. Here, we
describe a different action of estrogens likely to contribute to tumor development-blocking …