Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

Human neurohormone vasopressin (AVP) is synthesized in overlapping regions in the
hypothalamus. It is mainly known for its vasoconstricting abilities, and it is responsible for the …

Protein phosphorylation plays a key role in vasopressin signaling in the renal-collecting
duct. Large-scale identification and quantification of phosphorylation events triggered by …

G protein stimulatory α-subunit (Gαs)-coupled heptahelical receptors regulate cell processes
largely through activation of protein kinase A (PKA). To identify signaling processes …

Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in
renal collecting duct cells. Using mass spectrometry, we previously demonstrated four …

Post-translational modification of mitochondrial proteins by phosphorylation or
dephosphorylation plays an essential role in numerous cell signaling pathways involved in …

The arginine vasopressin (AVP) type 2 receptor (V2R) is unique among AVP receptor
subtypes in signaling through cAMP. Its key function is in the kidneys, facilitating the urine …

Our understanding of urinary concentrating and diluting mechanisms at the end of the 20th
century was based largely on data from renal micropuncture studies, isolated perfused …

Water excretion is regulated in large part through the regulation of osmotic water
permeability of the renal collecting duct epithelium. Water permeability is controlled by …

Vasopressin's action in renal cells to regulate water transport depends on protein
phosphorylation. Here we used mass spectrometry–based quantitative phosphoproteomics …