Vitamin D and the epigenome

IS Fetahu, J Höbaus, E Kállay - Frontiers in physiology, 2014 - frontiersin.org
Epigenetic mechanisms play a crucial role in regulating gene expression. The main
mechanisms involve methylation of DNA and covalent modifications of histones by …

[HTML][HTML] Regulation and role of EZH2 in cancer

H Yamaguchi, MC Hung - Cancer research and treatment …, 2014 - synapse.koreamed.org
Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

[HTML][HTML] Diverse involvement of EZH2 in cancer epigenetics

P Völkel, B Dupret, X Le Bourhis… - American journal of …, 2015 - ncbi.nlm.nih.gov
EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes
methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target …

EZH2 in normal hematopoiesis and hematological malignancies

L Herviou, G Cavalli, G Cartron, B Klein… - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive
complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 …

MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription

X Cheng, Y Yang, Z Fan, L Yu, H Bai, B Zhou, X Wu… - Oncogene, 2015 - nature.com
Malignant tumors are exemplified by excessive proliferation and aggressive
migration/invasion contributing to increased mortality of cancer patients. Matrix …

[HTML][HTML] EZH2-mediated repression of GSK-3β and TP53 promotes Wnt/β-catenin signaling-dependent cell expansion in cervical carcinoma

Q Chen, PS Zheng, WT Yang - Oncotarget, 2016 - ncbi.nlm.nih.gov
Enhancer of zeste homolog 2 (EZH2), a catalytic core component of the Polycomb
repressive complex 2 (PRC2), stimulates the silencing of target genes through histone H3 …

Targeting histone methylation for colorectal cancer

T Huang, C Lin, LLD Zhong, L Zhao… - Therapeutic …, 2017 - journals.sagepub.com
As a leading cause of cancer deaths worldwide, colorectal cancer (CRC) results from
accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation …

The role of p-STAT3 as a prognostic and clinicopathological marker in colorectal cancer: a systematic review and meta-analysis

K Ji, M Zhang, Q Chu, Y Gan, H Ren, L Zhang… - PLoS …, 2016 - journals.plos.org
Objective High expression of phosphorylated signal transducer and activator of transcription
3 (p-STAT3) has been detected in a variety of human tumors. However, the association of …

Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes

PK Singh, PR van den Berg, MD Long, A Vreugdenhil… - BMC genomics, 2017 - Springer
Background The nuclear hormone receptor superfamily acts as a genomic sensor of diverse
signals. Their actions are often intertwined with other transcription factors. Nuclear hormone …

Role of the EZH2/miR-200 axis in STAT3-mediated OSCC invasion Corrigendum in/10.3892/ijo. 2023.5528

Y Wang, W Guo, Z Li, Y Wu, C Jing… - International …, 2018 - spandidos-publications.com
Abnormal activation of signal transducer and activator of transcription 3 (STAT3) serves a
pivotal role in oral squamous cell carcinoma (OSCC) tumor cell invasion into normal tissues …