Neurological and psychiatric disorders are a category of chronic diseases that are
widespread and pose serious mental and physical health problems for patients. The …

Tryptophan (TRP) is an essential dietary amino acid that, unless otherwise committed to
protein synthesis, undergoes metabolism via the Tryptophan-Kynurenine (TRP-KYN) …

Background Tryptophan (TRP) is an essential amino acid that must be provided in the diet.
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …

Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated
signaling pathways. Recent studies have highlighted the significant role of transition metal …

Parkinson's disease (PD) is characterised by progressive death of dopamine (DA) neurons
in the substantia nigra pars compacta (SNpc) and pathological accumulation of α-synuclein …

Depression is a complicated neuropsychiatric condition with an incompletely understood
etiology, making the discovery of effective therapies challenging. Animal models have been …

Abstract Kynurenine‐3‐monooxygenase (KMO) is a mitochondrial enzyme involved in the
eukaryotic kynurenine pathway (KP), which is the major catabolic route of tryptophan. KMO …

The complex network of factors that contribute to neurodegeneration have hampered the
discovery of effective preventative measures. While much work has focused on brain-first …

Quinolinic acid (QA) is an index for some diseases, whose detection is of importance. This
work presents a samarium metal–organic framework (Sm-MOF) containing 5 …

MAOs are flavoenzymes that aid in the oxidative deamination of neurotransmitters such as
dopamine, serotonin, and epinephrine. MAO inhibitors are antidepressants that act by …