Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human
disease modeling, with an enormous potential to serve as paradigm shifting platforms for …

A major hurdle for cardiovascular disease researchers has been the lack of robust and
physiologically relevant cell-based assays for drug discovery. Derivation of cardiomyocytes …

Salt-inducible kinases (SIKs) are key regulators of cellular metabolism and growth, but their
role in cardiomyocyte plasticity and heart failure pathogenesis remains unknown. Here, we …

Heart failure with preserved left ventricular ejection fraction (HFpEF) has emerged as one of
the largest unmet needs in cardiovascular medicine. HFpEF is increasing in prevalence and …

Embryos devoid of autonomic innervation suffer sudden cardiac death. However, whether
autonomic neurons have a role in heart development is poorly understood. To investigate if …

Studies in hypertension (HTN) pharmacogenomics seek to identify genetic sources of
variable antihypertensive drug response. Genetic association studies have detected single …

The development of cardiovascular pathologies is partly attributed to epigenetic causes,
including histone methylation, which appears to be an important marker in hearts that …

Background: Indices of left ventricular (LV) structure and geometry represent useful
intermediate phenotypes related to LV hypertrophy (LVH), a predictor of cardiovascular (CV) …

Human pluripotent stem cell derivatives show promise as an in vitro platform to study a
range of human cardiovascular diseases. A better understanding of the biology of stem cells …

Purpose: Radiation-induced heart disease caused by cardiac exposure to ionizing radiation
comprises a variety of cardiovascular effects. Research in this field has been hampered by …