CD8+ T cells are a pivotal part of the immune response to viruses, playing a key role in
disease outcome and providing long-lasting immunity to conserved pathogen epitopes …

Tumor exome and RNA sequencing data provide a systematic and unbiased view on cancer-
specific expression, over-expression, and mutations of genes, which can be mined for …

Tumor exomes provide comprehensive information on mutated, overexpressed genes and
aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of …

Background Human telomerase reverse transcriptase (hTERT) is an antigen that may
represent a target for a novel anti-cancer strategy. A pilot, phase I study tested the safety and …

Epitope mapping has emerged as a powerful tool to design vaccines. It proved itself a
number of times to reveal the building blocks of potent immuno-prophylactics. T-cell epitope …

Fibroblast activation protein (FAPα) is a tumor stromal antigen expressed by cancer-
associated fibroblasts (CAFs) in more than 90% of malignant epithelial carcinomas. FAPα …

The study of peptide repertoires presented by major histocompatibility complex (MHC)
molecules and the identification of potential T-cell epitopes contribute to a multitude of …

The interrogation of cell surface–presented immunogenic epitopes is of great importance to
differentiate diseased cells in consequence to malignant transformation or viral infections …

Introduction: The advent of cancer immunotherapy is going to profoundly transform the
therapy of cancer. In this context, therapeutic cancer vaccines will offer significant …

Several cancer vaccine efforts have been directed to simultaneously cotarget multiple tumor
antigens, with the intent to achieve broader immune responses and more effective control of …