Hedgehog (Hh) signaling is critical for embryonic development and in differentiation,
proliferation, and maintenance of multiple adult tissues. De-regulation of the Hh pathway is …

Gastric HCl secretion by the parietal cell involves the secretagogue‐regulated re‐cycling of
the H+–K+‐ATPase at the apical membrane. The trafficking of the H+–K+‐ATPase and the …

Ezrin, a member of a family of proteins involved in the interaction of the microfilament
cytoskeleton with the plasma membrane, plays a role in membrane translocation in gastric …

Overexpression in insect cells of the full coding sequence of the human membrane
cytoskeletal linker ezrin (1-586) was compared with that of a NH2-terminal domain (ezrin 1 …

Phosphorylation of the membrane-cytoskeleton linker protein ezrin has been functionally
linked to acid secretion and vesicle recruitment to the apical secretory membrane in gastric …

Cultured rabbit parietal cells were used to evaluate morphological responses to activators
and inhibitors of HCl secretion. Immunofluorescence was used to localize the proton pump …

Kir4. 1 channels were found to colocalize with the H+/K+-ATPase throughout the parietal cell
(PC) acid secretory cycle. This study was undertaken to explore their functional role. Acid …

In our previous papers [eg Sato et al., J. Biol. Chem. 273 (1998) 21455–21462], we have
shown that prodigiosins can uncouple various H+-ATPases through their H+/Cl− symport …

Prodigiosin, prodigiosin 25-C, and metacycloprodigiosin all strongly inhibited the
acidification activity of (H++ K+)-ATPase on membrane vesicles from hog gastric mucosa …

Results: In examined patients, HGMUEs were associated with inflammation, chronic
gastritis, hiatus hernia, duodenal bulb erosion and ulcer and infection of H. pylori. Intestinal …