Multipotent mesenchymal stem cells (MSCs) have been considerably inspected as effective
tool for cell-based therapy of inflammatory, immune-mediated, and degenerative diseases …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine,
are being widely tested for the treatment of a variety of human diseases. No one factor has …

Background Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we
previously reported that peripheral infusion of human umbilical cord mesenchymal stem …

The worldwide increase in the prevalence of diabetes mellitus has raised the demand for
new therapeutic strategies targeting diabetic symptoms and its chronic complications …

Cell therapies aim to repair the mechanisms underlying disease initiation and progression,
achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in …

Mesenchymal stromal cells (MSCs) harbor great therapeutic potential for numerous
diseases. From early clinical trials, success and failure analysis, bench-to-bedside and back …

Background Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta
cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option …

Regenerative medicine relying on cell and gene therapies is one of the most promising
approaches to repair tissues. Multipotent mesenchymal stem/stromal cells (MSC), a …

Stem cell aging is a process in which stem cells progressively lose their ability to self-renew
or differentiate, succumb to senescence or apoptosis, and eventually become functionally …