Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

H Feng, YB Zhang, JF Gui, SM Lemon… - PLoS …, 2021 - journals.plos.org
The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

[HTML][HTML] Mnk kinase pathway: Cellular functions and biological outcomes

S Joshi, LC Platanias - World journal of biological chemistry, 2014 - ncbi.nlm.nih.gov
The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and
Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

H Xu, J Zhu, S Smith, J Foldi, B Zhao, AY Chung… - Nature …, 2012 - nature.com
Emerging concepts suggest that the functional phenotype of macrophages is regulated by
transcription factors that define alternative activation states. We found that RBP-J, the main …

The schlafen family of proteins and their regulation by interferons

E Mavrommatis, EN Fish… - Journal of Interferon & …, 2013 - liebertpub.com
The Schlafen (SLFN) family of proteins includes several mouse and human members. There
is emerging evidence that members of this family of proteins are involved in important …

The oncogene eIF4E: using biochemical insights to target cancer

M Carroll, KLB Borden - Journal of Interferon & Cytokine Research, 2013 - liebertpub.com
The eukaryotic translation initiation factor eIF4E is overexpressed in many human
malignancies where it is typically a harbinger of poor prognosis. eIF4E is positioned as a …

Progress in developing MNK inhibitors

X Jin, R Yu, X Wang, CG Proud, T Jiang - European Journal of Medicinal …, 2021 - Elsevier
The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

J Chen, X Feng, MJ Desierto… - Blood, The Journal …, 2015 - ashpublications.org
Interferon gamma (IFN-γ) has been reported to have both negative and positive activity on
hematopoietic cells, adding complexity to the interpretation of its pleiotropic functions. We …

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

JK Altman, A Szilard, BW Konicek… - Blood, The Journal …, 2013 - ashpublications.org
Mnk kinases regulate the phosphorylation and activation of the eukaryotic initiation factor 4E
(eIF4E), a protein that plays key roles in the initiation of messenger RNA translation and …

Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) as targets for cancer therapy: recent progress in the development of MNK …

A Dreas, M Mikulski, M Milik… - Current medicinal …, 2017 - ingentaconnect.com
MAP kinase-interacting kinases (MNK1 and MNK2) are often activated downstream of ERK
and p38 MAPK in the MAP kinase family. The role of MNKs in the development and …

Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes

EN Fish, LC Platanias - Molecular Cancer Research, 2014 - AACR
IFNs are cytokines with important antiproliferative activity and exhibit key roles in immune
surveillance against malignancies. Early work initiated over three decades ago led to the …