There are three families of glucose transporters in the human genome, SLC2, SLC5 and
SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The human …

SGLT inhibitors are important drugs for glycemic control in diabetes mellitus. Although the
contribution of SGLT1 for absorption of glucose from the intestine as well as SGLT2/SGLT1 …

IgA nephropathy (IgAN) is the leading cause of kidney failure due to an incomplete
understanding of its pathogenesis. We perform single-cell RNA sequencing (RNA-seq) on …

Na+-glucose cotransporter-2 (SGLT2) inhibitors are the new mainstay of treatment for
diabetes mellitus and cardiovascular diseases. Despite the remarkable benefits, the …

The human Na+-glucose cotransporter SGLT2 is expressed mainly in the kidney proximal
convoluted tubule where it is considered to be responsible for the bulk of glucose …

In the post-genomic era, biological studies are characterized by the rapid development and
wide application of a series of" omics" technologies, including genomics, proteomics …

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises
potassium chloride cotransporters (KCCs, eg KCC1, KCC2, KCC3, and KCC4)-mediated …

Multiplexed isobaric tag based quantitative proteomics and phosphoproteomics strategies
can comprehensively analyze drug treatments effects on biological systems. Given the role …

The activity of the renal thiazide-sensitive NaCl cotransporter (NCC) in the distal convoluted
tubule plays a key role in defining arterial blood pressure levels. Increased or decreased …

The thick ascending limb plays a key role in maintaining water and electrolyte balance. The
importance of this segment in regulating blood pressure is evidenced by the effect of loop …