Targeting heat shock proteins in cancer

G Jego, A Hazoumé, R Seigneuric, C Garrido - Cancer letters, 2013 - Elsevier
Heat shock proteins (HSPs) HSP27, HSP70 and HSP90 are powerful chaperones. Their
expression is induced in response to a wide variety of physiological and environmental …

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties

C Garrido, M Brunet, C Didelot, Y Zermati, E Schmitt… - Cell cycle, 2006 - Taylor & Francis
Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety
of physiological and environmental insults including anticancer chemotherapy, thus allowing …

Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy

E Schmitt, M Gehrmann, M Brunet… - Journal of Leucocyte …, 2007 - academic.oup.com
Stress or heat shock proteins (HSPs) are the most conserved proteins present in both
prokaryotes and eukaryotes. Their expression is induced in response to a wide variety of …

Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer

DH Zhang, LK Tai, LL Wong, LL Chiu, SK Sethi… - Molecular & Cellular …, 2005 - ASBMB
The receptor tyrosine kinase ErbB2 (HER-2/neu) is overexpressed in up to 30% of breast
cancers and is associated with poor prognosis and an increased likelihood of metastasis …

Hsp70 in cancer: A double agent in the battle between survival and death

MA Vostakolaei, L Hatami‐Baroogh… - Journal of cellular …, 2021 - Wiley Online Library
The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …

Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat‐shock proteins (Hsp27, Hsp70, GRP78) up‐regulation and their associated prognostic …

JM Luk, CT Lam, AFM Siu, BY Lam, IOL Ng… - …, 2006 - Wiley Online Library
To facilitate the identification of candidate molecular biomarkers that are linked to the
pathogenesis of hepatocellular carcinoma (HCC), we investigated protein‐expression …

Heat shock proteins: endogenous modulators of apoptotic cell death

C Didelot, E Schmitt, M Brunet, L Maingret… - Molecular chaperones in …, 2006 - Springer
The highly conserved heat shock proteins (Hsps) accumulate in cells exposed to heat and a
variety of other stressful stimuli. Hsps, that function mainly as molecular chaperones, allow …

Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

C Didelot, D Lanneau, M Brunet, AL Joly… - Current medicinal …, 2007 - ingentaconnect.com
Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist
the proteins in their folding, stability, assembly into multi-protein complexes and transport …

Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma

TL Hwang, Y Liang, KY Chien, JS Yu - Proteomics, 2006 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a common malignancy with a very low 5‐year
survival rate. Currently, there are no valid markers for early detection and targets for therapy …

Identification of over-expressed proteins in oral squamous cell carcinoma (OSCC) patients by clinical proteomic analysis

WY Lo, MH Tsai, Y Tsai, CH Hua, FJ Tsai, SY Huang… - Clinica Chimica …, 2007 - Elsevier
BACKGROUND: Oral cancer is a worldwide problem. It is a universal aggressive disease in
the population of smoking and drinking. The oral cancer mortality has been ranked 5th place …