Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

Heat shock protein 27 (HSP27) is traditionally viewed as an intracellular chaperone protein
with anti-apoptotic properties. However, recent data indicate that a number of heat shock …

The small heat-shock protein HSP27 is a redox-sensitive molecular chaperone that is
expressed throughout the human body. Here, we describe redox-induced changes to the …

Non-enzymatic posttranslational modifications are believed to affect at least 30% of human
proteins, commonly termed glycation. Many of these modifications are implicated in various …

Oxidative stress is the main cause of acute myocardial infarction (AMI), which is related to
the disorder of the regulation of Bmal1 on the redox state. HSPB1 form homologous …

Isothiocyanates (ITCs), such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN),
are effective cancer chemopreventive compounds. It is believed that the major mechanism …

This is a short paper on new ways to think about the structure and function of small heat
shock proteins (sHSPs), perhaps the most enigmatic family among protein chaperones. The …

The formation of acellular capillaries in the retina, a hallmark feature of diabetic retinopathy,
is caused by apoptosis of endothelial cells and pericytes. The biochemical mechanism of …

Cisplatin is a highly successful and widely used chemotherapy for the treatment of various
solid malignancies in both adult and pediatric patients. Side effects of cisplatin treatment …

Heat shock proteins (HSPs) are essential molecular chaperones that protect cells by aiding
in protein folding and preventing aggregation under stress conditions. Small heat shock …