In their natural habitats, unicellular fungal microbes are exposed to a myriad of mechanical
cues such as shear forces from fluid flow, osmotic changes, and contact forces arising from …

Human protein kinase C (PKC) isoforms have been implicated in diseases such as
Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes …

Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell
wall synthesis and provides the basis for the development of antifungal drugs. A set of five …

Signal transduction pathways regulating cell wall integrity (CWI) in filamentous fungi have
been studied taking into account findings in budding yeast, and much knowledge has been …

Surface receptors of animal cells, such as integrins, promote mechanosensation by forming
clusters as signaling hubs that transduce tensile forces. Walled cells of plants and fungi also …

The cell wall is a structure external to the plasma membrane that is essential for the survival
of the fungi. This polysaccharidic structure confers resistance to the cell internal turgor …

The survival of eukaryotic organisms during environmental changes is largely dependent on
the adaptive responses elicited by signal transduction cascades, including those regulated …

The cell wall (CW) is a thin and rigid layer encasing the membrane of all plant and fungal
cells. It ensures mechanical integrity by bearing mechanical stresses derived from large …

How growing cells cope with size expansion while ensuring mechanical integrity is not
known. In walled cells, such as those of microbes and plants, growth and viability are both …

Coupling cell wall expansion with cell growth is a universal challenge faced by walled
organisms. Mutations in Schizosaccharomyces pombe css1, which encodes a PM inositol …