The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury

AI Faden, J Wu, BA Stoica… - British journal of …, 2016 - Wiley Online Library
Traumatic brain injury (TBI) has been linked to dementia and chronic neurodegeneration.
Described initially in boxers and currently recognized across high contact sports, the …

Role of inflammation in suicide: from mechanisms to treatment

L Brundin, EY Bryleva… - …, 2017 - nature.com
Suicidal behavior is complex and manifests because of a confluence of diverse factors. One
such factor involves dysregulation of the immune system, which has been linked to the …

[HTML][HTML] Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?

AI Faden, DJ Loane - Neurotherapeutics, 2015 - Elsevier
It has long been suggested that prior traumatic brain injury (TBI) increases the subsequent
incidence of chronic neurodegenerative disorders, including Alzheimer disease, Parkinson …

Priming the inflammatory pump of the CNS after traumatic brain injury

KG Witcher, DS Eiferman, JP Godbout - Trends in neurosciences, 2015 - cell.com
Traumatic brain injury (TBI) can lead to secondary neuropsychiatric problems that develop
and persist years after injury. Mounting evidence indicates that neuroinflammatory …

The role of cytokines in the pathophysiology of suicidal behavior

L Ganança, MA Oquendo, AR Tyrka… - …, 2016 - Elsevier
Objective Immune dysregulation has been implicated in depression and other psychiatric
disorders. What is less clear is how immune dysregulation can affect risk of suicidal …

The inflammatory continuum of traumatic brain injury and Alzheimer's disease

ON Kokiko-Cochran, JP Godbout - Frontiers in immunology, 2018 - frontiersin.org
The post-injury inflammatory response is a key mediator in long-term recovery from
traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated by microglia …

The role of inflammation in suicidal behaviour

L Brundin, S Erhardt, EY Bryleva… - Acta Psychiatrica …, 2015 - Wiley Online Library
Objective Over the past decade, clinical data have accumulated showing that inflammation
might contribute to the pathophysiology of suicide. To evaluate the associations and to …

Systemic inflammation persists the first year after mild traumatic brain injury: results from the prospective trondheim mild traumatic brain injury study

V Chaban, GJB Clarke, T Skandsen, R Islam… - Journal of …, 2020 - liebertpub.com
Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and
successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate …

Inflammation in traumatic brain injury

TT Postolache, A Wadhawan, A Can… - Journal of …, 2020 - content.iospress.com
There is an increasing evidence that inflammation contributes to clinical and functional
outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing …