Transforming growth factor‐β (TGF‐β) plays a complex role during carcinogenesis. It may
either act as a tumor suppressor through its broad antiproliferative potential or as a tumor …

The five members of the inhibitor of growth (ING) gene family have garnered significant
interest due to their putative roles as tumor suppressors. However, the precise role (s) of …

Abstract Neuropilin (Nrp)-1 and Nrp-2 are multifunctional proteins frequently expressed by
cancer cells and contribute to tumor progression by mechanisms that are not well …

SMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor
cancer outcomes. Thus, it is critical to understand the upstream signaling pathways that …

Human malignant melanoma is highly resistant to chemotherapy and current
immunotherapeutic approaches induce long term remission only in the minority of patients …

In the past decade, our understanding of the molecular mechanisms that underlie breast
cancer pathology and progression has dramatically improved. Using this knowledge, we …

Prodigiosins are a family of bright red colored bacterial pigment and derive their name from
the miraculous (prodigious) events associated with their occurrence. They indeed seem to …

Transforming growth factor-β (TGF-β) is a multifunctional cytokine implicated in many
diseases, including tissue fibrosis and cancer. TGF-β mediates diverse biological responses …

Breast carcinoma is the most common cancer of women. Bones are often involved with
breast carcinoma metastases with the resulting morbidity and reduced quality of life. Breast …

Background The complexity of the human plasma proteome represents a substantial
challenge for biomarker discovery. Proteomic analysis of genetically engineered mouse …