Sixty-six years have elapsed since the discovery of fetuin in 1944, but its importance in
mammalian physiology has only recently been appreciated. Fetuin, first isolated from fetal …

Chronic kidney disease (CKD) affects approximately 13% of the US population and is
associated with increased risk of cardiovascular complications. Once renal replacement …

Background. This prospective, randomized, controlled trial compared the progression of
vascular and cardiac valve calcification in 360 prevalent adult hemodialysis patients with …

Masafumi Fukagawa, 1 Keitaro Yokoyama, 1 Fumihiko Koiwa, 1 Masatomo Taniguchi, 1
Tetsuo Shoji, 1 Junichiro James Kazama, 1 Hirotaka Komaba, 1 Ryoichi Ando, 1 Takatoshi …

Background Developing strategies for managing coronary artery calcification (CAC) in
patients with CKD is an important clinical challenge. Experimental studies have …

Results In patients randomized to sevelamer, all-cause mortality and the composite end
point were lower; a nonsignificant trend was noted for dialysis inception. Conclusions …

Coronary artery calcification is more prevalent in dialysis patients than in patients without
kidney disease and this is associated with high serum phosphorus. In this study, we …

Fetuin-A is an important inhibitor of extraosseous calcification, but some of the studies that
used ELISAs did not identify a significant relationship between serum fetuin-A levels and …

Abstract Background. Vascular calcifications (VCs) are frequently observed in chronic
kidney disease (CKD) and haemodialysis (HD) patients. They have been associated with …

Introduction: Observational studies have shown that high dietary intake of vitamin K2 is
associated with reduced risk of coronary vascular disease and vascular calcification …