Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Atrial fibrillation (AF) is the most frequent cardiac arrhythmia in clinical practice. AF is often
associated with profound functional and structural alterations of the atrial myocardium that …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Aims Atrial fibrillation (AF) is associated with altered cAMP/PKA signaling and an AF-
promoting reduction of L-type Ca2+-current (ICa, L), the mechanisms of which are poorly …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it causes substantial
mortality. The autonomic nervous system, and particularly the adrenergic/cholinergic …

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

Objectives: This study was designed to examine whether a cyclic adenosine
monophosphate (cAMP) phosphodiesterase (PDE), PDE4, is expressed in human atrium …

Aims Ageing-related cardiac disorders such as heart failure and atrial fibrillation often
present with intracellular calcium homeostasis dysfunction. However, knowledge of the …

Aims Atrial fibrillation (AF) produces rapid changes in the electrical properties of the atria
(electrical remodelling) that promote its own recurrence. In chronic AF (CAF) patients, up …