Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage
and regulated release of calcium and as the entrance to the secretory pathway. Protein …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Radiation therapy (RT) is used for local tumor control through direct killing of tumor cells.
Radiation-induced cell death can trigger tumor antigen-specific immune responses, but …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the
endoplasmic reticulum that is essential for establishing a hierarchical immune response …

Calreticulin is an ER (endoplasmic reticulum) luminal Ca2+-buffering chaperone. The
protein is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

The field of endoplasmic reticulum (ER) stress in mammalian cells has expanded rapidly
during the past decade, contributing to understanding of the molecular pathways that allow …