Epistasis and intramolecular networks in protein evolution
Proteins are molecular machines composed of complex, highly connected amino acid
networks. Their functional optimization requires the reorganization of these intramolecular …
networks. Their functional optimization requires the reorganization of these intramolecular …
Toward physics‐based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants
The goal of precision medicine is to utilize our knowledge of the molecular causes of
disease to better diagnose and treat patients. However, there is a substantial mismatch …
disease to better diagnose and treat patients. However, there is a substantial mismatch …
[HTML][HTML] Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase
The β-lactamase BlaC conveys resistance to a broad spectrum of β-lactam antibiotics to its
host Mycobacterium tuberculosis but poorly hydrolyzes third-generation cephalosporins …
host Mycobacterium tuberculosis but poorly hydrolyzes third-generation cephalosporins …
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance
Class A serine β-lactamases (SBLs) are key antibiotic resistance determinants in Gram-
negative bacteria. SBLs neutralize β-lactams via a hydrolytically labile covalent acyl …
negative bacteria. SBLs neutralize β-lactams via a hydrolytically labile covalent acyl …
Combination of AgNPs and domiphen is antimicrobial against biofilms of common pathogens
L Hu, X Yang, J Yin, X Rong, X Huang… - International Journal …, 2021 - Taylor & Francis
Purpose The aim was to evaluate the antimicrobial potential of AgNPs synthesized with
Artemisia argyi leaf extract and investigate the antimicrobial synergistic effects of AgNPs …
Artemisia argyi leaf extract and investigate the antimicrobial synergistic effects of AgNPs …
Slow protein dynamics elicits new enzymatic functions by means of epistatic interactions
MA Rossi, T Palzkill, FCL Almeida… - Molecular Biology and …, 2022 - academic.oup.com
Protein evolution depends on the adaptation of these molecules to different functional
challenges. This occurs by tuning their biochemical, biophysical, and structural traits through …
challenges. This occurs by tuning their biochemical, biophysical, and structural traits through …
Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase
The Klebsiella pneumoniae carbapenemase-2 (KPC-2) is a common source of antibiotic
resistance in Gram-negative bacterial infections. KPC-2 is a class A β-lactamase that …
resistance in Gram-negative bacterial infections. KPC-2 is a class A β-lactamase that …
Evaluation of tebipenem hydrolysis by β-lactamases prevalent in complicated urinary tract infections
Z Sun, L Su, N Cotroneo, I Critchley… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Tebipenem pivoxil is the first orally available carbapenem antibiotic and has been approved
in Japan for treating ear, nose, and throat and respiratory infections in pediatric patients. Its …
in Japan for treating ear, nose, and throat and respiratory infections in pediatric patients. Its …
Global epidemiology of CTX-M-type β-lactam resistance in human and animal
C Rana, S Rajput, M Behera, D Gautam, V Vikas… - … and Infectious Diseases, 2022 - Elsevier
Abstract CTX-M ESBL are widely found in animal and human infections. For better
understanding of CTX-M variations and epidemiology, a total of 2210 CTX-M sequences …
understanding of CTX-M variations and epidemiology, a total of 2210 CTX-M sequences …
Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors
M Perbandt, N Werner, A Prester, H Rohde… - Scientific reports, 2022 - nature.com
Abstract β-lactamases are a major cause of rapidly emerging and spreading antibiotic
resistance. Currently β-lactamase inhibitors (BLIs) in clinical use act only on Ambler Class A …
resistance. Currently β-lactamase inhibitors (BLIs) in clinical use act only on Ambler Class A …