Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening
MAM Aboul-Soud, AJ Alzahrani, A Mahmoud - Cells, 2021 - mdpi.com
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …
to the field of regenerative medicine, paving way for identifying the true potential of human …
Stem cells for cancer therapy: translating the uncertainties and possibilities of stem cell properties into opportunities for effective cancer therapy
AF Aldoghachi, ZX Chong, SK Yeap… - International Journal of …, 2023 - mdpi.com
Cancer recurrence and drug resistance following treatment, as well as metastatic forms of
cancer, are trends that are commonly encountered in cancer management. Amidst the …
cancer, are trends that are commonly encountered in cancer management. Amidst the …
Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies
The RB1 gene is frequently mutated in human cancers but its role in tumorigenesis remains
incompletely defined. Using an induced pluripotent stem cell (iPSC) model of hereditary …
incompletely defined. Using an induced pluripotent stem cell (iPSC) model of hereditary …
Li–Fraumeni syndrome–associated dimer-forming mutant p53 promotes transactivation-independent mitochondrial cell death
Cancer-relevant mutations in the oligomerization domain (OD) of the p53 tumor suppressor
protein, unlike those in the DNA binding domain, have not been well elucidated. Here, we …
protein, unlike those in the DNA binding domain, have not been well elucidated. Here, we …
Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism
Osteosarcoma (OS), the most common primary bone tumor, is highly metastatic with high
chemotherapeutic resistance and poor survival rates. Using induced pluripotent stem cells …
chemotherapeutic resistance and poor survival rates. Using induced pluripotent stem cells …
[HTML][HTML] Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome
Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder
characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes …
characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes …
Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation
The commitment of stem cells to differentiate into osteoblasts is a highly regulated and
complex process that involves the coordination of extrinsic signals and intrinsic …
complex process that involves the coordination of extrinsic signals and intrinsic …
Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas
DI Petrescu, JT Yustein, A Dasgupta - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Sarcomas comprise between 10–15% of all pediatric malignancies. Osteosarcoma and
Ewing sarcoma are the two most common pediatric bone tumors diagnosed in children and …
Ewing sarcoma are the two most common pediatric bone tumors diagnosed in children and …
LncRNA H19 suppresses osteosarcomagenesis by regulating snoRNAs and DNA repair protein complexes
Osteosarcoma is one of the most frequent common primary malignant tumors in childhood
and adolescence. Long non-coding RNAs (lncRNAs) have been reported to regulate the …
and adolescence. Long non-coding RNAs (lncRNAs) have been reported to regulate the …
Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
Missense mutations in the DNA binding domain of p53 are characterized as structural or
contact mutations based on their effect on the conformation of the protein. These mutations …
contact mutations based on their effect on the conformation of the protein. These mutations …