In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Pancreatic cancer is a malignancy with poor prognosis and high mortality. The recent
increase in pancreatic cancer incidence and mortality has resulted in an increased number …

Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …

Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …

Background Colorectal cancer defined as cancer of the colon or rectum, is the third most
frequently diagnosed cancer in men and the second in women, and, according to the World …

Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …

Pancreatic cancer usually results in poor survival with limited options for treatment, as most
affected individuals present with advanced disease. Early detection of preinvasive …

Identifying individuals with hereditary syndromes allows for improved cancer surveillance,
risk reduction, and optimized management. Establishing criteria for assessment allows for …

Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with
identification of new genes. Similarly, a better understanding of the genotype/phenotype …