The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

All living organisms depend on tightly regulated cellular networks to control biological
functions. Proteolysis is an important irreversible post-translational modification that …

Consisting of a defined set of extracellular proteins secreted from resident cells and with
minor contributions from serum proteins, the extracellular matrix (ECM) is an essential …

Tumor chemoresistance is often a major cause for the failure of chemotherapy. The
resistance of hepatocellular carcinoma (HCC) cells to sorafenib significantly limits its …

Background Colorectal cancer (CRC) is one of the most common malignant tumors,
influenced by several genetic loci in its clinical phenotypes. The aim of this study was to …

Objectives We aim to evaluate salivary matrix metalloproteinases (MMP-8) levels in oral
submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) for the purpose of …

肿瘤细胞外基质(ECM) 是肿瘤微环境的重要成分, ECM 的多样化和复杂的相互作用构成了肿瘤
微环境丰富的异质性, 在肿瘤的生长, 休眠, 耐药和复发转移过程发挥了巨大作用. 以DDR1 …

Cancer is a leading cause of death worldwide and novel prognostic factors are reported with
increasing numbers. Systematic reviews and meta-analyses on cumulative research data …