Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

Sex steroids are chief regulators of gender differences in the skeleton, and male gender is
one of the strongest protective factors against osteoporotic fractures. This advantage in bone …

Introduction The application of high-resolution peripheral quantitative computed tomography
(HR-pQCT) to assess bone microarchitecture has grown rapidly since its introduction in …

Rates of fracture worldwide are changing. Using the Clinical Practice Research Datalink
(CPRD), age, and gender, geographical, ethnic and socioeconomic trends in fracture rates …

High-resolution peripheral computed tomography (HR-pQCT) was developed to image bone
microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in …

Objective and design Patients with type 2 diabetes mellitus (T2D) have an increased fracture
risk despite a normal or elevated bone mineral density (BMD). The aim of this cross …

The primary goal of this cross‐sectional in vivo study was to assess peripheral bone
microarchitecture, bone strength, and bone remodeling in adult type 1 diabetes (T1D) …

The second generation HR-pQCT scanner (XtremeCTII, Scanco Medical) can assess human
bone microarchitecture of peripheral limbs with a 61 μm nominal isotropic voxel size. This is …

Although projections from cross‐sectional studies have shown that bone loss leading to
osteoporosis begins around menopause in women and later in life in men, this has not been …

Osteoporosis does not only affect postmenopausal women, but also ageing men. The
burden of disease is projected to increase with higher life expectancy both in females and …