Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

Importance Chronic subdural hematoma (CSDH) is a trauma-associated condition
commonly found in elderly patients. Surgery is currently the treatment of choice, but it carries …

Background Neuroinflammation is an important secondary injury mechanism that has dual
beneficial and detrimental roles in the pathophysiology of traumatic brain injury (TBI) …

Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause
of death and adult disability worldwide. Various pharmacological agents have been …

Stroke is the world's leading cause of disability with limited brain repair treatments which
effectively improve long‐term neurological deficits. The neuroinflammatory responses …

Ischemic stroke (IS) has complex pathological mechanisms, and is extremely difficult to treat.
At present, the treatment of IS is mainly based on intravenous thrombolysis and mechanical …

Neuronal apoptosis is one of the main pathological processes of hypoxic‐ischemic brain
damage (HIBD) and is involved in the development of hypoxic‐ischemic encephalopathy …

Depression is a highly prevalent disorder of the central nervous system. The
neuropsychiatric symptoms of clinical depression are persistent and include fatigue …

Statins beside their main effect on reducing the progression of cardiovascular disease
through pharmacological inhibition of the endogenous cholesterol synthesis, have …