Potential applications of plant biotechnology against SARS-CoV-2

T Capell, RM Twyman, V Armario-Najera, JKC Ma… - Trends in plant …, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus
responsible for an ongoing human pandemic (COVID-19). There is a massive international …

Molecular farming–the slope of enlightenment

R Fischer, JF Buyel - Biotechnology advances, 2020 - Elsevier
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …

Expression of recombinant antibodies

A Frenzel, M Hust, T Schirrmann - Frontiers in immunology, 2013 - frontiersin.org
Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …

Regulatory approval and a first‐in‐human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

JKC Ma, J Drossard, D Lewis, F Altmann… - Plant biotechnology …, 2015 - Wiley Online Library
Although plant biotechnology has been widely investigated for the production of clinical‐
grade monoclonal antibodies, no antibody products derived from transgenic plants have yet …

Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways

S Naqvi, C Zhu, G Farre, K Ramessar… - Proceedings of the …, 2009 - National Acad Sciences
Vitamin deficiency affects up to 50% of the world's population, disproportionately impacting
on developing countries where populations endure monotonous, cereal-rich diets …

Advances in plant molecular farming

OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize

C Zhu, S Naqvi, J Breitenbach… - Proceedings of the …, 2008 - National Acad Sciences
Combinatorial nuclear transformation is a novel method for the rapid production of multiplex-
transgenic plants, which we have used to dissect and modify a complex metabolic pathway …

Affinity chromatography as a tool for antibody purification

BV Ayyar, S Arora, C Murphy, R O'Kennedy - Methods, 2012 - Elsevier
The global antibody market has grown exponentially due to increasing applications in
research, diagnostics and therapy. Antibodies are present in complex matrices (eg serum …

Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond

V Yusibov, SJ Streatfield, N Kushnir - Human vaccines, 2011 - Taylor & Francis
In the last few years, plants have become an increasingly attractive platform for recombinant
protein production. This builds on two decades of research, starting with transgenic …

Plant molecular pharming for the treatment of chronic and infectious diseases

E Stoger, R Fischer, M Moloney… - Annual review of plant …, 2014 - annualreviews.org
Plant molecular pharming has emerged as a niche technology for the manufacture of
pharmaceutical products indicated for chronic and infectious diseases, particularly for …