Glycosylation: mechanisms, biological functions and clinical implications

M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Simple sugars to complex disease—mucin-type O-glycans in cancer

MR Kudelka, T Ju, J Heimburg-Molinaro… - Advances in cancer …, 2015 - Elsevier
Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-
linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by …

Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era

MD Bartholoma, AS Louie, JF Valliant… - Chemical …, 2010 - ACS Publications
The objective of medical imaging using molecular probes and perfusion radiotracers is to
provide rapid, noninvasive evaluation of physiology, pathology, and/or organ function. The …

Phototoxic aptamers selectively enter and kill epithelial cancer cells

CSM Ferreira, MC Cheung, S Missailidis… - Nucleic acids …, 2009 - academic.oup.com
The majority of cancers arise from malignant epithelial cells. We report the design of
synthetic oligonucleotides (aptamers) that are only internalized by epithelial cancer cells …

Hydrazinonicotinic acid (HYNIC)–Coordination chemistry and applications in radiopharmaceutical chemistry

LK Meszaros, A Dose, SCG Biagini, PJ Blower - Inorganica Chimica Acta, 2010 - Elsevier
HYNIC (hydrazinonicotinamide) is an efficient bifunctional chelator for Tc-99m used for
labelling biomolecules for molecular imaging. Developments and enhancements to improve …

Selecting potential targetable biomarkers for imaging purposes in colorectal cancer using TArget Selection Criteria (TASC): a novel target identification tool

M van Oosten, LMA Crane, J Bart… - Translational …, 2011 - Elsevier
Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis.
However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy …

Mucin glycans: A target for cancer therapy

L Sun, Y Zhang, W Li, J Zhang, Y Zhang - Molecules, 2023 - mdpi.com
Mucin glycans are an important component of the mucus barrier and a vital defence against
physical and chemical damage as well as pathogens. There are 20 mucins in the human …

Monoclonal antibody conjugated magnetic nanoparticles could target MUC‐1‐positive cells in vitro but not in vivo

S Shanehsazzadeh, C Gruettner… - Contrast media & …, 2015 - Wiley Online Library
MUC1 antigen is recognized as a high‐molecular‐weight glycoprotein that is unexpectedly
over‐expressed in human breast and other carcinomas. In contrast, C595 a monoclonal …

MUC1-targeted radiopharmaceuticals in cancer imaging and therapy

F Maleki, F Rezazadeh, K Varmira - Molecular pharmaceutics, 2021 - ACS Publications
Mucin 1 (MUC1) is a large, transmembrane mucin glycoprotein overexpressed in most
adenocarcinomas and plays an important role in tumor progression. Regarding its cellular …

Targeting glycans and heavily glycosylated proteins for tumor imaging

RD Houvast, M Vankemmelbeke, LG Durrant… - Cancers, 2020 - mdpi.com
Simple Summary Distinguishing malignancy from healthy tissue is essential for oncologic
surgery. Targeted imaging during an operation aids the surgeon to operate better. The …