Antiviral effect of high-dose ivermectin in adults with COVID-19: a proof-of-concept randomized trial
A Krolewiecki, A Lifschitz, M Moragas, M Travacio… - …, 2021 - thelancet.com
Background There are limited antiviral options for the treatment of patients with COVID-19.
Ivermectin (IVM), a macrocyclic lactone with a wide anti-parasitary spectrum, has shown …
Ivermectin (IVM), a macrocyclic lactone with a wide anti-parasitary spectrum, has shown …
Modeling favipiravir antiviral efficacy against emerging viruses: from animal studies to clinical trials
V Madelain, F Mentré, S Baize… - CPT …, 2020 - Wiley Online Library
In 2014, our research network was involved in the evaluation of favipiravir, an anti‐influenza
polymerase inhibitor, against Ebola virus. In this review, we discuss how mathematical …
polymerase inhibitor, against Ebola virus. In this review, we discuss how mathematical …
[HTML][HTML] Public health impact of Paxlovid as treatment for COVID-19, United States
We evaluated the population-level benefits of expanding treatment with the antiviral drug
Paxlovid (nirmatrelvir/ritonavir) in the United States for SARS-CoV-2 Omicron variant …
Paxlovid (nirmatrelvir/ritonavir) in the United States for SARS-CoV-2 Omicron variant …
Phase 2a, open-label, dose-escalating, multi-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza
Background The pharmacokinetics and appropriate dose regimens of favipiravir are
unknown in hospitalized influenza patients; such data are also needed to determine dosage …
unknown in hospitalized influenza patients; such data are also needed to determine dosage …
Modeling mitigation of influenza epidemics by baloxavir
Z Du, C Nugent, AP Galvani, RM Krug… - Nature …, 2020 - nature.com
Abstract Influenza viruses annually kill 290,000–650,000 people worldwide. Antivirals can
reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of …
reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of …
Comparing antiviral strategies against COVID-19 via multiscale within-host modelling
F Fatehi, RJ Bingham, EC Dykeman… - Royal Society …, 2021 - royalsocietypublishing.org
Within-host models of COVID-19 infection dynamics enable the merits of different forms of
antiviral therapy to be assessed in individual patients. A stochastic agent-based model of …
antiviral therapy to be assessed in individual patients. A stochastic agent-based model of …
A theoretical framework for transitioning from patient-level to population-scale epidemiological dynamics: influenza A as a case study
Multi-scale epidemic forecasting models have been used to inform population-scale
predictions with within-host models and/or infection data collected in longitudinal cohort …
predictions with within-host models and/or infection data collected in longitudinal cohort …
The mechanisms for within-host influenza virus control affect model-based assessment and prediction of antiviral treatment
Models of within-host influenza viral dynamics have contributed to an improved
understanding of viral dynamics and antiviral effects over the past decade. Existing models …
understanding of viral dynamics and antiviral effects over the past decade. Existing models …
High-resolution epidemic simulation using within-host infection and contact data
Background Recent epidemics have entailed global discussions on revamping epidemic
control and prevention approaches. A general consensus is that all sources of data should …
control and prevention approaches. A general consensus is that all sources of data should …