Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

AMP-activated protein kinase: the current landscape for drug development

GR Steinberg, D Carling - Nature reviews Drug discovery, 2019 - nature.com
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Anti-obesity effects of polyphenol intake: Current status and future possibilities

M Boccellino, S D'Angelo - International journal of molecular sciences, 2020 - mdpi.com
The prevalence of obesity has steadily increased worldwide over the past three decades.
The conventional approaches to prevent or treat this syndrome and its associated …

AMPK as a therapeutic target for treating metabolic diseases

EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice

P Wang, D Li, W Ke, D Liang, X Hu… - International Journal of …, 2020 - nature.com
Objective Resveratrol (RSV) is a natural polyphenol with putative anti-obesity effects;
however, its mechanisms of action remain unclear due to its low bioavailability. Microbial …

Inflammation and oxidative stress in an obese state and the protective effects of gallic acid

PV Dludla, BB Nkambule, B Jack, Z Mkandla, T Mutize… - Nutrients, 2018 - mdpi.com
Metabolic complications in an obese state can be aggravated by an abnormal inflammatory
response and enhanced production of reactive oxygen species. Pro-inflammatory response …

Resveratrol, metabolic syndrome, and gut microbiota

A Chaplin, C Carpéné, J Mercader - Nutrients, 2018 - mdpi.com
Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic
syndrome-related alterations in experimental animals, including glucose and lipid …

[HTML][HTML] A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications

DD Huang, G Shi, Y Jiang, C Yao, C Zhu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Diabetes mellitus (DM) is a major world health problem and one of the most studied
diseases, which are highly prevalent in the whole world, it is frequently associated with …

Induction of adipose tissue browning as a strategy to combat obesity

A Kuryłowicz, M Puzianowska-Kuźnicka - International journal of …, 2020 - mdpi.com
The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …

Molecular mechanisms of adipogenesis: the anti-adipogenic role of AMP-activated protein kinase

B Ahmad, CJ Serpell, IL Fong… - Frontiers in molecular …, 2020 - frontiersin.org
Obesity is now a widespread disorder, and its prevalence has become a critical concern
worldwide, due to its association with common co-morbidities like cancer, cardiovascular …