The gene regulatory code and grammar remain largely unknown, precluding our ability to
link phenotype to genotype in regulatory sequences. Here, using a massively parallel …

Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms
are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched~ 3 …

Background While the evolutionary divergence of cis-regulatory sequences impacts
translation initiation sites (TISs), the implication of tandem repeats (TRs) in TIS selection …

Across biological systems, a number of genomic processes, including transcription,
replication, DNA repair, and transcription factor binding, display intrinsic directionalities …

Mutation density patterns reveal unique biological properties of specific genomic regions
and shed light on the mechanisms of carcinogenesis. Although previous studies reported …

Findings in yeast and human suggest that evolutionary divergence in cis-regulatory
sequences impact translation initiation sites (TISs). Here we employed the TIS homology …