The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …

Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

Alzheimer's disease (AD) poses an ever-increasing public health concern as the population
ages, affecting more than 6 million Americans. AD patients present with mood and sleep …

Amyloid beta peptide (Aβ) and hyperphosphorylated neuronal tau proteins accumulate in
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …

Since Alzheimer's disease (AD) is a complex and multifactorial neuropathology, the
discovery of multi-targeted inhibitors has gradually demonstrated greater therapeutic …

Fyn is a Src kinase that controls critical signalling cascades and has been implicated in
learning and memory. Postsynaptic enrichment of Fyn underpins synaptotoxicity in …

Both Fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in
many tauopathies, including Alzheimer's disease (AD). Individual genetic ablation of fyn or …

Currently, no effective therapeutics exist for the treatment of incurable neurodegenerative
diseases such as Alzheimer's disease (AD). The cellular prion protein (PrPC) acts as a high …

Epilepsy and Alzheimer's disease share some common pathologies such as
neurodegeneration, seizures and impaired cognition. However, the molecular mechanisms …

Cumulative data suggest the involvement of Fyn tyrosine kinase in Alzheimer's disease
(AD). Previously, our group has shown increased immunoreactivities of the FynT isoform in …