Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Forty years of research have established that the p53 tumor suppressor provides a major
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …

The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …