Signaling through secretion of small molecules is a hallmark of both nervous and immune
systems. The scope and influence of the intense message exchange between these two …

Many now believe the holy grail for the next stage of therapeutic advance surrounds the
development of disease-modifying approaches aimed at intercepting the year-on-year …

The use of statins for bone regeneration is a promising and growing area of research.
Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy …

Backgrounds There are contradictory evidence about the effect of statins on depression.
This 6‐week‐randomized placebo‐controlled clinical trial assessed the efficacy and safety …

Background Recent evidence indicates that lipophilic statins have a neuroprotective benefit
in animal models of Parkinson's disease (PD). The objective of this study was to evaluate …

In this study, we examined the effect of chronic administration of simvastatin immediately
after status epilepticus (SE) on rat brain with temporal lobe epilepsy (TLE). First, we …

Summary Objective Statins (3‐hydroxy‐3‐methylglutaryl‐coenzyme A [HMG‐CoA]
reductase inhibitors) exert cholesterol‐independent pleiotropic effects that include …

Background Status epilepticus (SE) is a severe condition that may lead to hippocampal cell
loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death …

Emergencies in epilepsy may be encountered in the home, en route to a nearby hospital, in
the emergency department (ED), in the hospital, or in an intensive care unit (ICU). Adequate …

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are potent
cholesterol-lowering drugs which also possess beneficial antioxidant, antiinflammatory …