Since its inception in 2000, metronomic chemotherapy has undergone major advances as
an antiangiogenic therapy. The discovery of the pro-immune properties of chemotherapy …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …

Lymph node metastasis is the major concern that causes death in colorectal cancers.
However, biomarkers for cancer metastasis are still lacking. In this study, we applied an LC …

Mammary tumors are a major health threat to women and female dogs. In both, metastasis of
the primary tumor to distant organs is the most common cause of tumor-related death …

The extracellular matrix (ECM) is made up of noncellular components that have special
properties for influencing cell behavior and tissue structure. Small leucine-rich …

The extracellular matrix (ECM) from perilesional and colorectal carcinoma (CRC), but not
healthy colon, sustains proliferation and invasion of tumor cells. We investigated the …

Introduction Previous studies have indicated that the small leucine-rich proteoglycan (SLR)
osteoglycin (OGN) is downregulated in various cancers, including squamous cervical …

Abstract NR4A1 (Nur77, TR3) is an orphan nuclear receptor that is overexpressed in
pancreatic cancer and exhibits pro-oncogenic activity. RNA interference of NR4A1 …