Plasticity of function is required for each of the anterior pituitary endocrine axes to support
alterations in the demand for hormone with physiological status and in response to …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

The pituitary gland contains six types of endocrine cells defined by hormones they secrete:
corticotrophs, melanotrophs, gonadotrophs, thyrotrophs, somatotrophs, and lactotrophs. All …

Coordination of an appropriate stress response is dependent upon anterior pituitary
corticotroph excitability in response to hypothalamic secretagogues and glucocorticoid …

Heterogeneity in homotypic cellular responses is an important feature of many biological
systems, and it has been shown to be prominent in most anterior pituitary hormonal cell …

The neuroendocrine systems of the hypothalamus are critical for survival and reproduction,
and are highly conserved throughout vertebrate evolution. Their roles in controlling body …

Mathematical models are increasingly important in biology, and testability is becoming a
critical issue. One limitation is that one model simulation tests a parameter set representing …

Inflammation is a complex process driven by the coordinated action of a vast number of pro-
and anti-inflammatory molecular mediators. While experimental studies have provided an …

Given the central role of the sinoatrial (SA) node in determining heart rate, there is a long
history of attempts to understand the rhythmic spontaneous beating of SA nodal cells. Since …

Calcium plays a major role in every neuron. Not only does it play a part in controlling the
membrane potential, but it is also a crucial ingredient of both the pre-synaptic and post …