Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of
mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical …

The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be
possible to regenerate injured heart muscle previously thought to be permanently scarred …

Objectives: The goal of this study was to conduct a direct head-to-head comparison of
different stem cell types in vitro for various assays of potency and in vivo for functional …

Stem cell transplantation, as used clinically, suffers from low retention and engraftment of the
transplanted cells. Inspired by the ability of platelets to recruit stem cells to sites of injury on …

Background—Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue
regeneration, and autologous CDCs are being tested clinically. However, autologous …

Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of
heart valves, arteries and myocardium by creating 'living'tissue replacements outside (in …

Integrins are heterodimeric, transmembrane receptors that are expressed in all cells,
including those in the heart. They participate in multiple critical cellular processes including …

Telocytes (TCs) form a cardiac network of interstitial cells. Our previous studies have shown
that TCs are involved in heterocellular contacts with cardiomyocytes and cardiac …

Stem cell transplantation is currently implemented clinically but is limited by low retention
and engraftment of transplanted cells and the adverse effects of inflammation and …