Background Women are commonly prescribed a variety of medications during pregnancy.
As most organ systems are affected by the substantial anatomical and physiological …

Background Achieving adequate antimalarial drug exposure is essential for curing malaria.
Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug …

Background Malaria elimination requires interruption of the highly efficient transmission of
Plasmodium parasites by mosquitoes. TB31F is a humanised monoclonal antibody that …

Abstract Background Malaria caused by Plasmodium falciparum in pregnancy can result in
adverse maternal and fetal sequelae. This review evaluated the adherence of the national …

Over the past 10 years, the available evidence on the treatment of malaria during pregnancy
has increased substantially. Owing to their relative ease of use, good sensitivity and …

Severe malaria in pregnancy is a large contributor to maternal morbidity and mortality.
Intravenous quinine has traditionally been the treatment drug of choice for severe malaria in …

Background The fixed dose combination of artemether-lumefantrine (AL) is the most widely
used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure …

Pregnancy-related physiological changes can alter the absorption, distribution, metabolism
and excretion of medicines which may affect the safety and efficacy of the medicines …

Background. Artemisinin-based combination therapy (ACT) is the first-line treatment of
Plasmodium falciparum malaria. Since the introduction of artemether-lumefantrine (AL) for …

Free drug concentrations are generally considered the pharmacologically active moiety and
are important for cellular diffusion and distribution. Pregnancy-related changes in plasma …