Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Chromatin landscapes are disrupted during DNA replication and must be restored faithfully
to maintain genome regulation and cell identity. The histone H3-H4 modification landscape …

The integrity of the nuclear envelope (NE) is essential for maintaining the structural stability
of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in …

Mobile transposable elements (TEs) not only participate in genome evolution but also
threaten genome integrity. In healthy cells, TEs that encode all of the components that are …

MacroH2A has established tumour suppressive functions in melanoma and other cancers,
but an unappreciated role in the tumour microenvironment. Using an autochthonous …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Herpes simplex virus (HSV-1) progeny form in the nucleus and exit to successfully infect
other cells. Newly formed capsids navigate complex chromatin architecture to reach the …

The histone H2A variant H2A. W occupies transposons and thus prevents access to them in
Arabidopsis thaliana. H2A. W is deposited by the chromatin remodeler DDM1, which also …