Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

Abstract Neurotensin receptor 1 (NTSR1) is a G-protein-coupled receptor (GPCR) that
engages multiple subtypes of G protein, and is involved in the regulation of blood pressure …

Purpose tumor-infiltrating immune cells are highly relevant to the progression and prognosis
of colorectal cancer (CRC). The aim of this study is to explore the immune cells and immune …

The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …

Our understanding of the regulation of appetite has improved considerably over the last few
decades. Recent work, stimulated by efforts aimed at curbing the current obesity epidemic …

Autism spectrum disorders (ASDs) have been associated with brain inflammation as
indicated by microglia activation, as well as brain expression and increased plasma levels of …

Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Transfer across the blood‐brain barrier (BBB) remains a significant hurdle for the
development of biopharmaceuticals with therapeutic effects within the central nervous …

Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …