Mammalian cells possess a multifaceted antioxidant enzyme system, which includes
superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione …

Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …

The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …

As a carrier of many biologically active compounds, blood is exposed to oxidants to a
greater extent than the intracellular environment. Serum albumin plays a key role in …

Selenium is an essential mineral element with important biological functions for the whole
body through incorporation into selenoproteins. This element is highly concentrated in the …

Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction
of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 …

Glutathione peroxidase 3 (GPx3), a major scavenger of reactive oxygen species (ROS) in
plasma, acts as a redox signal modulator. However, the mechanism underlying GPx3 …

Background Growing evidence has demonstrated that glutathione peroxidases (GPXs)
family genes play critical roles in onset and progression of human cancer. However, a …

Information regarding transcriptome and metabolome has significantly contributed to
identifying potential therapeutic targets for the management of a variety of cancers. Obesity …