TH2 cell development and function

JA Walker, ANJ McKenzie - Nature Reviews Immunology, 2018 - nature.com
Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …

The airway epithelium in asthma

BN Lambrecht, H Hammad - Nature medicine, 2012 - nature.com
Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Functions of T cells in asthma: more than just TH2 cells

CM Lloyd, EM Hessel - Nature reviews immunology, 2010 - nature.com
Asthma has been considered a T helper 2 (TH2) cell-associated inflammatory disease, and
TH2-type cytokines, such as interleukin-4 (IL-4), IL-5 and IL-13, are thought to drive the …

Toll-like receptor agonists as adjuvants for allergen immunotherapy

ME Kirtland, DC Tsitoura, SR Durham… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptors (TLRs) are essential components of innate immunity and provide
defensive inflammatory responses to invading pathogens. Located within the plasma …

[HTML][HTML] Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases

J Miyata, M Arita - Allergology International, 2015 - Elsevier
Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are
found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with …

Pattern recognition receptors in innate immunity, host defense, and immunopathology

R Suresh, DM Mosser - Advances in physiology education, 2013 - journals.physiology.org
Infection by pathogenic microbes initiates a set of complex interactions between the
pathogen and the host mediated by pattern recognition receptors. Innate immune responses …

The microbiology of asthma

MR Edwards, NW Bartlett, T Hussell… - Nature Reviews …, 2012 - nature.com
Asthma remains an important human disease that is responsible for substantial worldwide
morbidity and mortality. The causes of asthma are multifactorial and include a complex mix …

Toll-like receptors

E Lien, RR Ingalls - Critical care medicine, 2002 - journals.lww.com
The ability of a host to sense invasion by pathogenic organisms and to respond
appropriately to control infection is paramount to survival. In the case of sepsis and septic …

IL‐28A (IFN‐λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

O Koltsida, M Hausding, A Stavropoulos… - EMBO molecular …, 2011 - embopress.org
Abstract IL‐28 (IFN‐λ) cytokines exhibit potent antiviral and antitumor function but their full
spectrum of activities remains largely unknown. Recently, IL‐28 cytokine family members …

Pattern‐recognition receptors in human eosinophils

AM Kvarnhammar, LO Cardell - Immunology, 2012 - Wiley Online Library
The pattern‐recognition receptor (PRR) family includes Toll‐like receptors (TLRs),
nucleotide‐binding oligomerization domain (NOD)‐like receptors (NLRs), RIG‐I‐like …