Background Plasminogen activator inhibitor‐1 (PAI‐1), the main inhibitor of fibrinolysis, is
frequently elevated in obesity and could potentially mediate the risk of venous …

A growing body of literature has attempted to characterize how traffic-related air pollution
(TRAP) affects molecular and subclinical biological processes in ways that could lead to …

Von Willebrand factor (VWF) is a glycoprotein synthesized and secreted by vascular
endothelial cells and megakaryocytes, found on plasma surface, endothelial cells, and α …

We examined whether specifically statins, of the major lipid modifiers (statins, proprotein
convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects …

Aims/hypothesis Growth differentiation factor 15 (GDF-15), a suggested biomarker for
metformin use, may explain the potential cardioprotective and anti-cancer properties of …

Background Testosterone supplementation has been linked to increased cardiovascular
disease risk in some observational studies. The causal role of testosterone can be …

Background Despite great progress in prevention and control, ischemic heart disease (IHD)
remains a leading cause of global morbidity and mortality. Diet plays a key role in IHD, but a …

APOE genotypes are associated with ischemic heart disease (IHD), several other
cardiovascular diseases and dementia. Previous studies have not comprehensively …

Atrial fibrillation (AF) has been associated with numerous diseases. However, whether AF is
a cause or consequence of these diseases is uncertain. To clarify, we assessed the causal …

Aims: Current cardiovascular (CV) risk prediction algorithms are able to quantify the
individual risk of CV disease. However, CV risk in young adults is underestimated due to the …