Primary microcephaly: do all roads lead to Rome?
GK Thornton, CG Woods - Trends in Genetics, 2009 - cell.com
The relatively large brain and expanded cerebral cortex of humans is unusual in the animal
kingdom and is thought to have promoted our adaptability and success as a species. One …
kingdom and is thought to have promoted our adaptability and success as a species. One …
Medicinal attributes of pyridine scaffold as anticancer targeting agents
EA Mohamed, NSM Ismail, M Hagras… - Future Journal of …, 2021 - Springer
Background The heterocyclic compounds particularly pyridine displayed clinical and
biological implementation. Pyridine scaffolds have been detected in most relevant drug …
biological implementation. Pyridine scaffolds have been detected in most relevant drug …
Personalized immunotherapy against several neuronal and brain tumors
S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Identification and validation of genes involved in cervical tumourigenesis
T Rajkumar, K Sabitha, N Vijayalakshmi, S Shirley… - BMC cancer, 2011 - Springer
Background Cervical cancer is the most common cancer among Indian women. This cancer
has well defined pre-cancerous stages and evolves over 10-15 years or more. This study …
has well defined pre-cancerous stages and evolves over 10-15 years or more. This study …
A Comprehensive Bioinformatics Analysis of UBE2C in Cancers
Ubiquitination is one of the main post-translational modification of proteins. It plays key roles
in a broad range of cellular functions, including protein degradation, protein interactions …
in a broad range of cellular functions, including protein degradation, protein interactions …
CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials
The Maternal Embryonic Leucine Zipper Kinase (MELK) has been reported to be a genetic
dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK …
dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK …
[HTML][HTML] Metabolism and brain cancer
SKN Marie, SMO Shinjo - Clinics, 2011 - Elsevier
Cellular energy metabolism is one of the main processes affected during the transition from
normal to cancer cells, and it is a crucial determinant of cell proliferation or cell death. As a …
normal to cancer cells, and it is a crucial determinant of cell proliferation or cell death. As a …
The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
R Kuner, M Fälth, NC Pressinotti, JC Brase… - Journal of molecular …, 2013 - Springer
Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate
cancer, increased activity of cell cycle genes has been associated with prognostic …
cancer, increased activity of cell cycle genes has been associated with prognostic …
MELK is not necessary for the proliferation of basal-like breast cancer cells
Thorough preclinical target validation is essential for the success of drug discovery efforts. In
this study, we combined chemical and genetic perturbants, including the development of a …
this study, we combined chemical and genetic perturbants, including the development of a …
Selection of suitable housekeeping genes for expression analysis in glioblastoma using quantitative RT-PCR
Background Considering the broad variation in the expression of housekeeping genes
among tissues and experimental situations, studies using quantitative RT-PCR require strict …
among tissues and experimental situations, studies using quantitative RT-PCR require strict …