Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

ContextMore persons in the United States die from non–small cell lung cancer (NSCLC)
than from breast, colorectal, and prostate cancer combined. In preclinical testing, oral …

The tumour-suppressor phosphatase with tensin homology (PTEN) is the most important
negative regulator of the cell-survival signalling pathway initiated by phosphatidylinositol 3 …

The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the
absence of cellular stress, the p53 protein is maintained at low steady-state levels and …

The ability to derive a whole-genome map of transcription-factor binding sites (TFBS) is
crucial for elucidating gene regulatory networks. Herein, we describe a robust approach that …

Background Bacterial infections have been linked to malignancies due to their ability to
induce chronic inflammation. We investigated the association of oral bacteria in oral …

Members of the class O of forkhead box transcription factors (FoxO) have important roles in
metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of …

Notch signalling participates in the development of multicellular organisms by maintaining
the self-renewal potential of some tissues and inducing the differentiation of others …

Epidermal growth factor receptor (EGFR) overexpression is common in head and neck
squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been …