Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

Abstract DNA methyltransferase 3A (DNMT3A) has been recognised as a key element of
epigenetic regulation in normal development, and the aberrant regulation of DNMT3A is …

Congenital heart disease (CHD) with extracardiac malformations (EM) is the most common
multiple malformation, resulting from the interaction between genetic abnormalities and …

Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known
as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the …

Differential methylation of imprinting control regions in mammals is essential for
distinguishing the parental alleles from each other and regulating their expression …

Genomic imprinting is found in marsupial and eutherian mammals, but not in monotremes.
While the primary regulator of genomic imprinting in eutherians is differential DNA …

The establishment of epigenetic marks during the reprogramming window is susceptible to
environmental influences, and stimuli during this critical stage can cause altered DNA …

There have been a number of recent insights in the area of genomic imprinting, the
phenomenon whereby one of two autosomal alleles is selected for expression based on the …

Primordial germ cells (PGCs) undergo dynamic epigenetic changes during development,
including genome-wide erasure of DNA methylation for the establishment of a clean …

Cloning by somatic cell nuclear transfer (SCNT) is an assisted reproductive technique with
several applications in livestock. However, it is still a technique that shows low efficiency due …