Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

In the last two decades, regenerative medicine has shown the potential for “bench‐to‐
bedside” translational research in specific clinical settings. Progress made in cell and stem …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease
modeling and the generation of tissue for renal replacement. Long-term application …

Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney
development and disease. We reproducibly differentiated three genetically distinct wild-type …

In the field of regenerative medicine, one of the ultimate goals is to generate functioning
organs from pluripotent cells, such as ES cells or induced pluripotent stem cells (PSCs). We …

Long-term preservation of complex engineered tissues and organs at cryogenic
temperatures in the absence of ice has been prevented to date by the difficulty of …

Differentiated cell types derived from human embryonic stem cells (hESCs) may serve in the
future to treat various human diseases. A crucial step toward their successful clinical …

A critical event during kidney organogenesis is the differentiation of podocytes, specialized
epithelial cells that filter blood plasma to form urine. Podocytes derived from human …

Decellularized (acellular) scaffolds, composed of natural extracellular matrix, form the basis
of an emerging generation of tissue-engineered organ and tissue replacements capable of …