Intracellular and extracellular interactions with proteins enables the functional and
mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described …

Gene therapy is a promising strategy for treating challenging diseases. The successful
delivery of genes is a critical step for gene therapy. However, concerns about …

Abstract siRNA‐mediated management of myocardial ischemia reperfusion (IR) injury is
greatly hampered by the inefficient myocardial enrichment and cardiomyocyte transfection …

Photodynamic therapy and adipose browning induction are two promising approaches to
reverse obesity. The former strategy acts rapidly and locally, whereas the latter has a more …

Devices resident in the stomach—used for a variety of clinical applications including
nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and …

Downregulating programmed cell death ligand 1 (PD‐L1) protein levels in tumor cells is an
effective way to achieve immune system activation for oncology treatment, but current …

Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and
lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and …

Cytosolic delivery is the major challenge that limits the clinical translation of siRNA-based
therapeutics. Although thousands of polymers have been developed for siRNA delivery, the …

CRISPR/Cas9 genome editing platforms are widely applied as powerful tools in basic
research and potential therapeutics for genome regulation. The appropriate alternative of …

Physiological characteristics of diseases bring about both challenges and opportunities for
targeted drug delivery. Various drug delivery platforms have been devised ranging from …